EZtrampo Instructions


EZtrampo analyzes mitochondrial protein-coding genes to study nucleotide composition across functional protein regions (transmembrane, mitochondrial matrix, inner mitochondrial space). It generates partitioned datasets suitable for phylogenetic analyses.

  • Reads FASTA files for the 13 mitochondrial protein-coding genes
  • Aligns sequences across species
  • Splits proteins into three regions:
    • TM: transmembrane
    • MA: mitochondrial matrix
    • IM: inner mitochondrial space
  • Calculates compositional statistics and codon usage
  • Produces graphical summaries
  • Generates NEXUS partition files by codon, gene, strand, and domain
  1. Upload FASTA files. Acceptable formats are: .fasta, .fa, .fsa, .fas, .fna, .ffn, .faa, .frn
  2. Each FASTA file must correspond to a single genetic marker and be named accordingly.
  3. Please ensure that:
    • only FASTA files are uploaded;
    • taxon names are consistent across genes;
    • sequences contain valid nucleotides only ( IUPAC ambiguity codes allowed );
    • internal gaps are absent (they will be removed if detected).
  4. Select the appropriate NCBI mitochondrial genetic code
  5. Choose the closest available model organism. Alternatively, users can provide a custom model by:
    • Selecting User as reference model
    • Uploading the reference mitochondrial gene sequence file (amino acids) following the required header format (see TRAMPO documentation)
    • Uploading the custom TMHMM table files generated with TMHMM software (.txt, one file per gene)
  6. Optionally, users can select a gene order reference from the dropdown menu.

Upload Your Files


Drag & drop files here
or click to select
Drag & drop FASTA file
or click to select
Required only if Reference Model = user
Drag & drop TMHMM table files
or click to select
Required only if Reference Model = user