EZcodon Instructions


EZcodon processes protein-coding mitochondrial genes to:

  1. Clean and pad sequences from FASTA files for each strand (Heavy/J or Light/N).
  2. Concatenate genes across taxa consistently.
  3. Compute codon usage metrics:
    • Relative Synonymous Codon Usage (RSCU)
    • Amino acid frequencies per species
  4. Generate plots:
    • Line plots (≤20 species) or box plots (>20 species) for amino acid frequencies
    • Stacked RSCU plots per strand for each species

Supports analysis for Heavy strand (J), Light strand (N), or both (JN).

  1. Prepare FASTA files for protein-coding genes for each strand. Each file is named by gene and may contain one or more sequences. Taxa must be named consistently across files.
  2. Accepted extensions: .fasta, .fa, .fsa, .fas, .fna, .ffn, .faa, .frn
  3. Upload either:
    • Only J genes
    • Only N genes
    • Both J and N genes
  4. Select the correct mitochondrial genetic code. More info
  5. Output includes:
    • RSCU CSV tables
    • Amino acid frequency CSV tables
    • PDF plots

Upload Your Files


Drag & drop J FASTA files here
or click to select multiple files
Drag & drop N FASTA files here
or click to select multiple files

Qualitative palettes

Continuous palettes

*If not provided, a random job ID will be assigned.